Hermann Frieboes
Assoc Professor
The goal of Dr. Frieboes' work is to apply physical sciences and engineering principles to better understand disease progression and treatment response. A main interest of this effort has been to dramatically improve cancer treatment outcomes: Dr. Frieboes' doctoral and post-doctoral work in biomedical engineering has focused on the interdisciplinary development and implementation of experimental biology, mathematical modeling, and computational simulation techniques that can be quantitatively integrated to characterize cancer growth and treatment response. As a faculty member in Bioengineering, ongoing projects in his laboratories include analysis and prediction of solid tumor progression, vascularization, and response as a function of microenvironmental characteristics and novel therapy modalities, including nanovectors and probes optimized to overcome transport barriers in the tumor microenvironment. In previous experience as an engineer in industry, Dr. Frieboes acquired knowledge and practice in system design and product development, theory and algorithms, software, and project/personnel management.
Education
- Ph.D. in Biomedical Engineering, University of California - Irvine, 2006
- M.S. in Computer Engineering, University of California - Irvine, 1993
- B.S. in Applied Mathematics, Physics, University of California - Irvine, 1991
- B.S. in Electrical Engineering, Computer Science, University of California, Irvine, 1987
Publications
Distribution of PLGA-modified Nanoparticles Targeting Hypo-Vascularized Cervical Cancer Tumors- 2017
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Journal Articles
- Miller, H., A. & Frieboes, H., B. (2019). Evaluation of drug-loaded gold nanoparticle cytotoxicity as a function of tumor tissue heterogeneity. Annals of Biomedical Engineering, 47, 257-271
- Chamseddine, I., Frieboes, H., B. & Kokkolaras, M. (2018). Design Optimization of Tumor Vasculature-Bound Nanoparticles. Scientific Reports, 9, 17768
- Bamji, S., van Berkel, V., Miller, D. & Frieboes, H., B. (2018). A review of metabolism-associated biomarkers in lung cancer diagnosis and treatment. Metabolomics, 14, 81
- Curtis, L., Berkel, V., V. & Frieboes, H., B. (2018). Pharmacokinetic/pharmacodynamic modeling of combination-chemotherapy for lung cancer. J Theor Biol, 448, 38-52
- Halwes, M., E., Tyo, K., M., Steinbach, J., M. & Frieboes, H., B. (2018). Computational Modeling of Antiviral Drug Diffusion from Poly(lactic-co-glycolic-acid) Fibers and Multicompartment Pharmacokinetics for Application to the Female Reproductive Tract. Molecular Pharmaceutics, 15, 1534-1547
- Mahlbacher, G., Curtis, L., T., Lowengrub, J. & Frieboes, H., B. (2018). Mathematical modeling of tumor-associated macrophage interactions with the cancer microenvironment. J Immunotherapy Cancer, 6(1), 10
- Ng, C., F. & Frieboes, H., B. (2018). Simulation of Multispecies Desmoplastic Cancer Growth via a Fully Adaptive Nonlinear Full Multigrid Algorithm. Frontiers in Physiology: Computational Physiology and Medicine, 9, 821
- Sims, L., B., Frieboes, H., B. & Steinbach, J., M. (2018). Nanoparticle-Mediated Drug Delivery to Treat Infections in the Female Reproductive Tract: Evaluation of Experimental Systems and the Potential for Mathematical Modeling. International Journal of Nanomedicine, 13, 2709-27
- Sims, L., B., Miller, H., A., Halwes, M., E., Steinbach, J., M. & Frieboes, H., B. (2018). Modeling of nanoparticle transport through the female reproductive tract for the treatment of infectious diseases. European Journal of Pharmaceutics and Biopharmaceutics, 18, 30634-9
- Yan, H., Romero-López, M., Benitez, L., Di, K., Frieboes, H., B., Hughes, C., Bota, D. & Lowengrub, J. (2018). Multiscale modeling of glioblastoma. Transl Cancer Res, 7((Suppl 1)), S96–S98
- Sims, L., B., Huss, M., K., Frieboes, H., B. & Steinbach-Rankins, J., M. (2017). Distribution of PLGA-modified nanoparticles in 3D cell culture models of hypo-vascularized tumor tissue.. Journal of nanobiotechnology, 15(1), 67
- Hudson, S., Dolin, C., Poole, L., Massey, V., Wilkey, D., Beier, J., Merchant, M., Frieboes, H., B. & Arteel, G. (2017). Modeling the Kinetics of Integrin Receptor Binding to Hepatic Extracellular Matrix Proteins. Scientific Reports
- Leonard, F., Curtis, L., T., Ware, M., Nosrat, T., Liu, X., Yokoi, K., Frieboes, H., B. & Godin, B. (2017). Macrophage polarization contributes to the anti-tumoral efficacy of mesoporous nanovectors loaded with albumin-bound paclitaxel. Frontiers in Immunology
- Lynch, C., Abdollahi, B., Fuqua, J., deCarlo, A., Bartholomai, J., Balgemann, R., van Berkel, V. & Frieboes, H., B. (2017). Prediction of lung cancer patient survival via supervised machine learning classification techniques. Int J Medical Informatics
- Lynch, C., van Berkel, V. & Frieboes, H., B. (2017). Application of unsupervised analysis techniques to lung cancer patient data. PLoS ONE
- Ng, C., F. & Frieboes, H., B. (2017). Model of Vascular Desmoplastic Multispecies Tumor Growth. J Theor Biology
- Reichel, D., Curtis, L., T., Ehlman, E., Evers, B., M., Rychahou, P., Frieboes, H., B. & Bae, Y. (2017). Development of Halofluorochromic Polymer Nanoassemblies for the Potential Detection of Liver Metastatic Colorectal Cancer Tumors Using Experimental and Computational Approaches. Pharmaceutical Research
- Tennill, T., Gross, M. & Frieboes, H., B. (2017). Analysis of co-localized protein expression in histologic sections of prostate cancer using an automated approach. PLoS ONE
- Ware, M., J., Curtis, L., T., Wu, M., Corr, S., J., Curley, S., A., Godin, B. & Frieboes, H., B. (2017). Pancreatic adenocarcinoma response to chemotherapy enhanced with non-invasive radio frequency evaluated via an integrated experimental/computational approach. Scientific Reports
- Yan, H., Romero-López, M., Benitez, L., Di, K., Frieboes, H., B., Hughes, C., Bota, D. & Lowengrub, J. (2017). 3D mathematical modeling of glioblastoma suggests that transdifferentiated vascular endothelial cells mediate resistance to current standard-of-care therapy. Cancer Research, 64(3), 538-548
- Yan, H., Romero-López, M., Frieboes, H., B., Hughes, C. & Lowengrub, J., S. (2017). Multiscale Modeling of Glioblastoma Supports the Partial Disruption of Vessel/Cancer Stem Cell Crosstalk to Achieve Tumor Regression without Increasing Invasiveness. IEEE Trans Biomed Eng
- Curtis, L., T., England, C., G., Wu, M., Lowengrub, J. & Frieboes, H., B. (2016). An interdisciplinary computational/experimental approach to evaluate drug-loaded gold nanoparticle tumor cytotoxicity. Nanomedicine (Lond.), 11(3), 197-216
- Curtis, L., T., Rychahou, P., Bae, Y. & Frieboes, H., B. (2016). An Experimental/Computational Assessment of Antitumor Activity of Polymer Nanoassemblies for pH-Controlled Drug Delivery to Primary and Metastatic Tumors. Pharm Research, 33(10), 2552-2664
- Halwes, M., Steinbach, J., M. & Frieboes, H., B. (2016). Pharmacokinetic modeling of a gel-delivered dapivirine microbicide in humans. Eur J Pharm Sci, 93, 410-418
- Leonard, F., Curtis, L., T., Tanei, T., Yesantharao, P., Alexander, J., F., Wu, M., Lowengrub, J., Liu, X., Ferrari, M., Yokoi, K., Frieboes, H., B. & Godin, B. (2016). Enhanced performance of macrophage-encapsulated nanoparticle albumin-bound-paclitaxel in hypo-perfused cancer lesions. Nanoscale, 8, 12544-12552
- Sims, L., Curtis, L., T., Frieboes, H., B. & Steinbach, J., M. (2016). Enhanced Uptake and Transport of PLGA-modified Nanoparticles in Cervical Cancer. J Nanobiotechnology, 14(1), 33
- Curtis, L., T., Wu, M., Lowengrub, J., Decuzzi, P. & Frieboes, H., B. (2015). Computational Modeling of Tumor Response to Drug Release from Vasculature-Bound Nanoparticles. PLoS ONE
- England, C., G., Gobin, A., M. & Frieboes, H., B. (2015). Evaluation of Uptake and Distribution of Gold Nanoparticles in Solid Tumors. Eur Phys J Plus
- England, C., Huang, J., S., James, K., T., Zhang, G., Gobin, A., M. & Frieboes, H., B. (2015). Detection of Phosphatidylcholine-Coated Gold Nanoparticles in Orthotopic Pancreatic Adenocarcinoma using Hyperspectral Imaging. PLoS ONE
- England, C., Miller, M., C., Kuttan, A., Trent, J., O. & Frieboes, H., B. (2015). Release Kinetics of Paclitaxel and Cisplatin from Two and Three Layered Gold Nanoparticles. Eur J Pharm Biopharm
- England, C., Ng, C., F., van Berkel, V. & Frieboes, H., B. (2015). A Review of Pharmacological Treatment Options for Lung Cancer: Emphasis on Novel Nanotherapeutics and Associated Toxicity. Curr Drug Targets
- Frieboes, H., B., Curtis, L., T., Wu, M., Kani, K. & Mallick, P. (2015). Simulation of the Protein Shedding Kinetics of a Fully Vascularized Tumor. Cancer Informatics
- Frieboes, H., B., Smith, B., R., Wang, Z., Kotsuma, M., Ito, K., Day, A., Cahill, B., Flinders, C., Mummenthaler, S., M., Mallick, P., Simbawa, E., AL-Fhaid, A., S., Mahmoud, S., R., Gambhir, S., S. & Cristini, V. (2015). Predictive modeling of drug response in Non-Hodgkin’s lymphoma. PLoS ONE
- Frieboes, H., B., Huang, J., S., Yin, W. & McNally, L., R. (2014). Chloroquine-mediated cell death in pancreatic adenocarcinoma through inhibition of autophagy. Journal of the Pancreas
- Hudson, S., V., Huang, J., S., Yin, W., Ableituni, S., Rush, J., Khanal, A., Yan, J., Ceresa, B., P., Frieboes, H., B. & McNally, L., R. (2014). Targeted noninvasive imaging of EGFR-expressing orthotopic pancreatic cancer using multispectral optoacoustic tomography. Cancer Research
- Wu, M., Frieboes, H., B., Chaplain, M., A., McDougall, S., R., Cristini, V. & Lowengrub, J., S. (2014). The effect of interstitial pressure on therapeutic agent transport: coupling with the tumor blood and lymphatic vascular systems. J Theor Biol
- England, C., Zhang, G., Sun, X., Priest, T., Patel, D., McNally, L., R., van Berkel, V., Gobin, A., M. & Frieboes, H., B. (2013). Enhanced penetration into 3D cell culture using two- and three-layered gold nanoparticles. Int J Nanomedicine, 8, 3603-17
- Frederick, P., J., Green, H., N., Huang, J., S., Egger, M., E., Frieboes, H., B., Grizzle, W., E. & McNally, L., R. (2013). Chemoresistance in ovarian cancer linked to expression of microRNAs. Biotechnic & Histochemistry, 88, 403-409
- Frieboes, H., B., Smith, B., R., Chuang, Y., L., Ito, K., Roettgers, A., M., Gambhir, S., S. & Cristini, V. (2013). An integrated computational/experimental model of lymphoma growth. PLoS Comp Biol, 9(3), e1003008
- Frieboes, H., B., Wu, M., Lowengrub, J., S., Decuzzi, P. & Cristini, V. (2013). A computational model for predicting nanoparticle accumulation in tumor vasculature. PLoS ONE, 8(2), e56876
- Khalifa, F., El-Ghar, M., A., Abdollahi, B., Frieboes, H., B., El-Diasty, T. & El-Baz, A. (2013). A Comprehensive Non-Invasive Framework for Automated Evaluation of Acute Renal Transplant Rejection Using DCE-MRI. NMR in Biomedicine, 26, 1460-1470
- Lee, J., J., Huang, J., S., England, C., McNally, L., R., Frieboes, H., B., Lee, J., Huang, J., England, C., McNally, L. & Frieboes, H. (2013). Predictive Modeling of In Vivo Response to Gemcitabine in Pancreatic Cancer. PLOS COMPUTATIONAL BIOLOGY, 9(9)
- Wu, M., Frieboes, H., B., McDougall, S., R., Chaplain, M., A., Cristini, V. & Lowengrub, J., S. (2013). The effect of interstitial pressure on tumor growth: coupling with the blood and lymphatic vascular systems. J Theor Biol, 320, 131-151
- van de Ven, A., Abdollahi, B., Martinez, C., Paskett, L., A., Landis, M., D., Chang, J., C., Ferrari, M., Frieboes, H., B., van de Ven, A., Abdollahi, B., Martinez, C., Burey, L., Landis, M., Chang, J., Ferrari, M. & Frieboes, H. (2013). Modeling of nanotherapeutics delivery based on tumor perfusion. NEW JOURNAL OF PHYSICS, 15(9)
- van de Ven, A., L., Wu, M., Lowengrub, J., McDougall, S., R., Chaplain, M., A., Cristini, V., Ferrari, M. & Frieboes, H., B. (2012). Integrated intravital microscopy and mathematical modeling to optimize nanotherapeutics delivery to tumors. AIP Advances, 2
- Frieboes, H., B., Chaplain, M., A., Thompson, A., M., Bearer, E., L., Lowengrub, J., S. & Cristini, V. (2011). Physical oncology: a bench-to-bedside quantitative and predictive approach. Cancer Research, 71, 298-302
- Phadke, A., P., Jay, C., M., Wang, Z., Chen, S., Liu, S., Haddock, C., Kumar, P., Pappen, B., Rao, D., D., Templeton, N., S., Webb, C., Monsma, D., Scott, S., Dylewski, D., Frieboes, H., B., Senzer, N., Maples, P., B., Nemunaitis, J. & Tong, A., W. (2011). In vivo safety and antitumor efficacy of bifunctional shRNAs specific for the human stathmin 1 (STMN1) oncoprotein. DNA Cell Biol(30), 715-726
- Pham, K., Frieboes, H., B., Cristini, V. & Lowengrub, J., S. (2011). Predictions of tumor morphological stability and evaluation against experimental observations. J Royal Soc Interface, 8, 16-29
- Chauviere, A., H., Hatzikirou, H., Lowengrub, J., S., Frieboes, H., B., Thompson, A., M. & Cristini, V. (2010). Mathematical Oncology: How Are the Mathematical and Physical Sciences Contributing to the War on Breast Cancer?. Curr Breast Cancer Rep, 2, 121-129
- Frieboes, H., B., Jin, F., Chuang, Y., L., Wise, S., M., Lowengrub, J., S. & Cristini, V. (2010). Three-dimensional multispecies tumor growth-II: Tumor invasion and angiogenesis. J Theor Biol, 264, 1254-1278
- Lowengrub, J., S., Frieboes, H., B., Jin, F., Chuang, Y., L., Li, X., Macklin, P., Wise, S., M. & Cristini, V. (2010). Nonlinear modeling of cancer: bridging the gap between cells and tumors. Nonlinearity, 23, R1-R91
- Bearer, E., L., Lowengrub, J., S., Frieboes, H., B., Chuang, Y., L., Jin, F., Wise, S., M., Ferrari, M., Agus, D., B. & Cristini, V. (2009). Multiparameter Computational Modeling of Tumor Invasion. Cancer Research, 69, 4493-4501
- Frieboes, H., B., Edgerton, M., E., Fruehauf, J., P., Rose, F., R., Worrall, L., K., Gatenby, R., A., Ferrari, M. & Cristini, V. (2009). Prediction of drug response in breast cancer using integrative experimental/ computational modeling. Cancer Research, 69, 4484-4492
- Sinek, J., P., Sanga, S., Zheng, X., Frieboes, H., B., Ferrari, M. & Cristini, V. (2009). Predicting drug pharmacokinetics and effect in vascularized tumors using computer simulation. J Math Biol, 58, 485-510
- Wise, S., M., Lowengrub, J., S., Frieboes, H., B. & Cristini, V. (2008). Nonlinear simulations of three-dimensional multispecies tumor growth-I: Model and numerical Method. J Theor Biol, 253, 524-543
- Frieboes, H., B., Lowengrub, J., S., Wise, S., M., Zheng, X., Bearer, E., L. & Cristini, V. (2007). Computer simulation of glioma growth and morphology. NeuroImage, 37, S59-S70
- Sanga, S., Frieboes, H., B., Bearer, E., L. & Cristini, V. (2007). Predictive oncology: a review of multidisciplinary, multiscale in silico modeling linking phenotype, morphology and growth. NeuroImage, 37, S120-S134
- Frieboes, H., B., Zheng, X., Sun, C., H., Tromberg, B., Gatenby, R. & Cristini, V. (2006). An Integrated Computational/Experimental Model of Tumor Invasion. Cancer Research, 66, 1597-1604
- Sanga, S., Sinek, J., P., Frieboes, H., B., Ferrari, M., Fruehauf, J., P. & Cristini, V. (2006). Mathematical Modeling of Cancer Progression and Response to Chemotherapy. Expert Rev Anticancer Ther, 6, 1361-1376
- Cristini, V., Frieboes, H., B., Gatenby, R., Caserta, S., Ferrari, M. & Sinek, J., P. (2005). Morphologic Instability and Cancer Invasion. Clinical Cancer Research, 11, 6772-6779
- Sinek, J., P., Frieboes, H., B., Zheng, X. & Cristini, V. (2004). Two-dimensional Chemotherapy Simulations Demonstrate Fundamental Transport and Tumor Response Limitations Involving Nanoparticles. Biomedical Microdevices, 6, 297-309
More about Hermann Frieboes
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- Highlight of research article: Simulation model predicts tumor invasion in marginal environmental conditions, 2006, Cancer Research journal
- Biomedical Engineering Discovery Newsletter, 2006, University of California, Irvine
- Highlight of research article: Multiparameter Computational Modeling of Tumor Invasion, 2009, Cancer Research journal
- Special feature of research article: Prediction of drug response in breast cancer using integrative experimental/computational modeling, 2009, American Association for Cancer Research
- Special feature of research article: Multiparameter Computational Modeling of Tumor Invasion, 2009, American Association for Cancer Research
- Front cover, 2010, Nonlinearity Journal
- Young Investigators Transnetwork Project Award, 2011, NCI Physical Sciences in Oncology
- NSF Career Development Workshop Fellowship, 2011, NSF -- UofL
- Article selected for inclusion, 2012, Virtual Journal of Biological Physics Research
- Article selected for inclusion, 2012, Virtual Journal of Nanoscale Science & Technology
- Investigator Profile, 2012, NCI Physical Sciences in Oncology Perspectives Quarterly
- Student Engineering Collaboration Award, 2012, Research!Louisville
- Outstanding Paper Award, 2013, ASME Global Congress on Nano Engineering for Medicine and Biology
- Faculty Favorite, 2013, UofL Delphi Center for Teaching and Learning
- NCI Cancer Education Program Norbert J. Burzynski Award, 2014, Research!Louisville
- Faculty Favorite, 2014, UofL Delphi Center for Teaching and Learning
- Student Award: Commencement Speaker, 2015, University of Louisville
- Student Award: Banner Bearer, 2015, School of Engineering
- Faculty Favorite, 2016, UofL Delphi Center for Teaching and Learning
- Faculty Favorite, 2017, UofL Delphi Center for Teaching and Learning
- Faculty Favorite, 2018, UofL Delphi Center for Teaching and Learning
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2019
Spring
- BE 420 - BIOSYSTEMS & SIGNALS
- BE 420 - BIOSYSTEMS & SIGNALS
- BE 693 - INDEPENDENT STUDY IN BE
2018
Fall
- BE 497 - BIOENGR DESIGN PROJECT - CUE
- BE 693 - INDEPENDENT STUDY IN BE
- BE 359 - CELL & MOLEC BIOL FOR BE
Spring
- BE 359 - CELL & MOLEC BIOL FOR BE
Summer
- BE 685 - MODELING OF BIOL PHENOMENA
2017
Fall
- BE 497 - BIOENGR DESIGN PROJECT - CUE
Spring
- BE 693 - INDEPENDENT STUDY IN BE
- BE 359 - CELL & MOLEC BIOL FOR BE
Summer
- BE 600 - ADVANCED TOPICS IN BE
2016
Fall
- BE 497 - BIOENGR DESIGN PROJECT - CUE
- BE 693 - INDEPENDENT STUDY IN BE
Spring
- BE 693 - INDEPENDENT STUDY IN BE
- BE 405 - PRACTICUM IN BE
- BE 359 - CELL & MOLEC BIOL FOR BE
Summer
- BE 600 - ADVANCED TOPICS IN BE
2015
Fall
- BE 497 - BIOENGR DESIGN PROJECT - CUE
- BE 693 - INDEPENDENT STUDY IN BE
Spring
- BE 310 - BIOTRANSPORT PHENOMENA
- BE 405 - PRACTICUM IN BE
Summer
- BE 593 - INDEPENDENT STUDY IN BE
- BE 600 - ADVANCED TOPICS IN BE
2014
Fall
- BE 497 - BIOENGR DESIGN PROJECT;CUE
Spring
- BE 310 - BIOTRANSPORT PHENOMENA
- BE 405 - PRACTICUM IN BE
Summer
- BE 600 - ADVANCED TOPICS IN BE
2013
Fall
- BE 497 - BIOENGR DESIGN PROJECT;CUE
Summer
- BE 600 - ADVANCED TOPICS IN BE