Xiao-An Fu
Professor
Xiao-An (Sean) Fu is a Professor of Chemical Engineering at the University of Louisville. He received his Ph.D. degree in Chemical Engineering from Case Western Reserve University. He was a researcher in the Department of Electrical Engineering and Computer Science at Case Western Reserve University before he joined the faculty of the University of Louisville in 2008. He was a key contributor to a number of research projects funded by DARPA and NASA including SiC MEMS and SiC JFET-based integrated circuits for high temperature applications. He invented a process for deposition of low stress polycrystalline SiC suitable as MEMS structure materials. His current research interests include chemical microsensors, microreactors, breath analysis for development of a noninvasive diagnostic tool for detection of early lung cancer, trace gas detection, active tuberculosis and other pulmonary diseases, analysis of neurotransmitter, and advanced semiconductor thin films for integrated circuit and solar cell applications. He has published more than 60 papers in refereed journals and conference proceedings. He has received three U.S. patents. Dr. Fu was a recipient of a visiting scholarship from the Chinese Academy of Sciences.
Education
- B.S. in Chemical Engineering, Jiangxi Polytechnic University, 1986
- M.S. in Chemical Engineering, The Chinese Academy of Science, 1989
- Ph.D. in Chemical Engineering, Case Western Reserve University, 2001
Publications
Journal Articles
- Xie, Z., Raju, M., Adhihetty, P., Fu, X. & Nantz, M., H. (2020). Effect of Thiol Molecular Structure on the Sensitivity of Gold Nanoparticle-Based Chemiresistors toward Carbonyl Compounds . Sensors, 20, 7024
- Fu, X., Rai, S., N., Das, S. & Pan, J. (2022). <span style="font-size:12pt;">Multigroup prediction in lung cancer patients and comparative controls using signature of volatile organic compounds in breath samples</span>. PLOS ONE, 0277431
- Fu, X. & Ando, T. (2019). Materials: silicon and beyond. Sensors and Actuators A: Physical, 296, 340-351
- Fu, X. (2023). <span style="font-size:12pt;">Analysis of a broad range of carbonyl compounds in exhaled breath by UHPLC-MS</span>. Analytical Chemistry, 95, 4344-4352
- Ogunwale, M., Verard, C., N., Knipp, R., Thompson, L., Nantz, M., H. & Fu, X. (2019). The Influence of β-Ammonium Substitution on the Reaction Kinetics of Aminooxy Condensations with Aldehydes and Ketones. ChemPhysChem, 20, 815-822
- Shaffie, A., Soliman, A., Fu, X., Nantz, M., H., Giridharan, G., A., van Berkel, V., H. & El-Baz, A., S. (2021). A novel technology to integrate imaging and clinical markers for non‑invasive diagnosis of lung cancer. Scientific Reports, 11, 4597
- Taylor, M., J., Chitwood, C., P., Xie, Z., van Berkel, V., Fu, X., Frieboes, H. & Suliman, S. (2024). Disease diagnosis and severity classification in pulmonary fibrosis using carbonyl volatile organic compounds in exhaled breath . Respiratory Medicine, 222, 107534
- Sutaria, S., R., Morris, J., D., Xie, Z., Marimuthu, S., Arnold, F., W., Huang, J., Fu, X. & Nantz, M., H. (2024). <span style="font-size:11pt;">A feasibility study on exhaled breath analysis using UV spectroscopy to detect COVID-19</span>. Journal of Breath Research, 18, 016004
- Chen, Y., Li, Q., Xie, Z. & Fu, X. (2019). Characterization of DNPH coated microrector chip for analysis of trace carbonyls with application for breath analysis. Journal of Chromatography B, 1106-1107, 58-63
- Conklin, D., Ogunwale, M., Chen, Y., Theis, W., Nantz, M., Fu, X., Chen, L., Bhatnagar, A. & Srivastava, S. (2018). Electronic cigarette-generated aldehydes: The contribution of e-liquid components to their formation and the use of urinary aldehyde metabolites as biomarkers of exposure. Aerosol Science and Technology, 52, 1219-1232
- Xie, Z., Raju, M., Stewart, A., Nantz, M. & Fu, X. (2018). Imparting Sensitivity and Selectivity to a Gold Nanoparticle Chemiresistor Through Thiol Monolayer Functionalization for Sensing Acetone. RSC Advances, 8, 35618-35624
- Li, M., Li, Q., Nantz, M. & Fu, X. (2018). Analysis of carbonyl compounds in ambient air by a microreactor approach. ACS Omega, 3, 6764-6769
- Ogunwale, M., Chen, Y., Nantz, M., H., Conklin, D. & Fu, X. (2017). Nicotine in electronic cigarette liquids and aerosols. Analytical Methods, 9, 4261-4266
- Ogunwale, M., Li, M., Raju, M., Chen, Y., Nantz, M. & Fu, X. (2017). Aldehyde detection in electronic cigarette aerosols. ACS Omega, 2, 1207-1214
- Schumer, E., Bousamra, M., Li, M., Fu, X. & van Berkel, V. (2016). Normalization of exhaled carbonyl compounds after lung cancer resection. Journal, 102, 1095-1100
- Knipp, R., Li, M., Fu, X., A. & Nantz, M., H. (2015). A versatile probe for chemoselective capture and analysis of carbonyl compounds in exhaled breath. Analytical Methods, 7, 6027-6033
- Li, M., Yang, D., Brock, G., Knipp, R., Bousamra II, M., Nantz, M., H. & Fu, X., A. (2015). Breath carbonyl compounds as biomarkers of lung cancer. Lung Cancer, 90(1), 92–97
- Schumer, E., M., Trivedi, J., R., Berkel, V., V., Black, M., C., Li, M., Fu, X., A. & Bousamra II, M. (2015). High sensitivity for lung cancer detection using analysis of exhaled carbonyl comounds. J. Thoracic Cardiovascular Surgery, 150(6), 1517-1523
- Bousamra, M., Schumer, E., ., Li, M., Nantz, M. & Fu, X. (2014). Quantitative analysis of exhaled carbonyl compounds distinguishes. The Journal of Thoracic and Cardiovascular Surgery, 148(3), 1074-1081
- Fu, X., Li, M., ., Knipp, R., Nantz, M. & Bousamra, M. (2014). Noninvasive detection of lung cancer using exhaled breath. Cancer Medicine, 3(1), 174-181
- Fu, X., Trevino, J., Mehregany, M. & Zorman, C., A. (2014). Doped polycrystalline 3C–SiC films with low stress for MEMS: part I. Deposition conditions and film properties. Journal, 24
- Trevino, J., Fu, X., Mehregany, M. & Zorman, C., A. (2014). Doped polycrystalline 3C–SiC films with low stress for MEMS: part II. Characterization using micromachined structures. Journal of Micromechanics and Microengineering, 24, 8
- Li, M., Biswas, S., Nantz, M., H., Higashi, R., M., Fu, X., Nantz, M., Higashi, R. & Fu, X. (2013). A microfabricated preconcentration device for breath analysis. SENSORS AND ACTUATORS B-CHEMICAL, 180(3), 130-136
- Miller, K., Li, M., Walsh, K. & Fu, X. (2013). The effects of DRIE operational parameters on vertically aligned micropillar arrays. JOURNAL OF MICROMECHANICS AND MICROENGINEERING, 23(3)
- Soong, C., Garverick, S., Fu, X., Patil, A. & Mehregany, M. (2013). A Fully Monolithic 6H-SiC JFET-Based Transimpedance Amplifier for High-Temperature Capacitive Sensing. IEEE TRANSACTIONS ON ELECTRON DEVICES, 60(12), 4146-4151
- Li, M., Biswas, S., Nantz, M., H., Higashi, R., M. & Fu, X. (2012). Preconcentration and analysis of trace volatile carbonyl compounds. Analytical Chemistry, 84(3), 1288-1293
- Soong, C., Patil, A., C., Garverick, S., L., Fu, X. & Mehregany, M. (2012). 550 degrees C integrated logic circuits using 6H-SiC JFETs. IEEE Electron Device Letters, 33(10), 1369-1371
- Adhihetty, P., K., Halder, S., Jasinski, J., Fu, X. & Nantz, M., H. (2023). <span style="font-size:12pt;">Harnessing the cation-π interactions of metalated gold monolayer-protected clusters to detect aromatic volatile organic compounds</span>. Talanta , 253, 123915
- Fu, X., Halder, S., Xie, Z. & Nantz, M., H. (2022). <span style="font-size:12pt;">Integration of a micropreconcentrator with solid-phase microextraction for analysis of trace volatile organic compounds by gas chromatography-mass spectrometry</span>. Journal of Chromatography A , 1673, 463083
- Fu, X., Shaffie, A., Soliman, A., Eledkawy, A., Nantz, M., H., Giridharan, G., A., van Berkel, V., H. & El-Baz, A., S. (2022). <span style="font-size:12pt;">Lung cancer diagnosis system based on volatile organic compounds (VOCs) profile measured in exhaled breath</span>. Applied Science, 12, 7165
- Fu, X., Sutaria, S., Morris, J., D., Xie, Z., Gori, S. & Nantz, M., H. (2022). <span style="font-size:12pt;"><span style="font-size:7pt;"> </span></span><span style="font-size:12pt;">Lipid peroxidation produces a diverse mixture of saturated and unsaturated aldehydes in exhaled breath that can serve as </span><span style="font-size:12pt;">biomarkers of lung cancer—A Review</span>. Metabolites, 12, 561
- Li, Q., Fu, X., Xu, H. & Jiang, N. (2021). <span style="font-size:12pt;">A stability study of carbonyl compounds in Tedlar bags by a fabricated MEMS microreactor approach</span>. Microchemical Journal , 160, 105611
More about Xiao-An Fu
- US Patent 9,638,965 "Noninvasive detection of lung cancer using exhaled breath", 2017, US Patent Office
- US Patent 8,663,581 "A preconcentrator and method of using the same", 2014, US Patent Office
2026
Spring
- CHE 461 - PROCESS CONTROL
Summer
- CHE 461 - PROCESS CONTROL
- CHE 312 - CHE THERMODYNAMICS II
Fall
- CHE 686 - CHEM ENGR ANALYSIS
2025
Spring
- CHE 461 - PROCESS CONTROL
Summer
- CHE 312 - CHE THERMODYNAMICS II
Fall
- CHE 686 - CHEM ENGR ANALYSIS
2024
Spring
- CHE 461 - PROCESS CONTROL
Summer
- CHE 312 - CHE THERMODYNAMICS II
Fall
- CHE 686 - CHEM ENGR ANALYSIS
2023
Spring
- CHE 461 - PROCESS CONTROL
Fall
- CHE 686 - CHEM ENGR ANALYSIS
Summer
- CHE 312 - CHE THERMODYNAMICS II
2022
Spring
- CHE 461 - PROCESS CONTROL
Summer
- CHE 312 - CHE THERMODYNAMICS II
Fall
- CHE 686 - CHEM ENGR ANALYSIS
2021
Spring
- CHE 253 - MATERIALS SCIENCE
Summer
- CHE 312 - CHE THERMODYNAMICS II
Fall
- CHE 686 - CHEM ENGR ANALYSIS
2020
Spring
- CHE 253 - MATERIALS SCIENCE
Fall
- CHE 686 - CHEM ENGR ANALYSIS
Summer
- CHE 312 - CHE THERMODYNAMICS II
2019
Spring
- CHE 253 - MATERIALS SCIENCE
- CHE 694 - SP TOP CHE
Fall
- CHE 686 - CHEM ENGR ANALYSIS
Summer
- CHE 312 - CHE THERMODYNAMICS II
2018
Spring
- CHE 253 - MATERIALS SCIENCE
Fall
- CHE 686 - CHEM ENGR ANALYSIS
Summer
- CHE 312 - CHE THERMODYNAMICS II
2017
Spring
- CHE 253 - MATERIALS SCIENCE
- CHE 694 - SP TOP CHE
Fall
- CHE 686 - CHEM ENGR ANALYSIS
Summer
- CHE 312 - CHE THERMODYNAMICS II
2016
Spring
- CHE 253 - MATERIALS SCIENCE
Fall
- CHE 686 - CHEM ENGR ANALYSIS
Summer
- CHE 312 - CHE THERMODYNAMICS II
2015
Spring
- CHE 253 - MATERIALS SCIENCE
Fall
- CHE 686 - CHEM ENGR ANALYSIS
Summer
- CHE 312 - CHE THERMODYNAMICS II
2014
Spring
- CHE 253 - MATERIALS SCIENCE
- CHE 694 - SP TOP CHE
Fall
- CHE 686 - CHEM ENGR ANALYSIS
Summer
- CHE 312 - CHE THERMODYNAMICS II
2013
Fall
- CHE 686 - CHEM ENGR ANALYSIS
Summer
- CHE 312 - CHE THERMODYNAMICS II
Xiao-An Fu
Professor Chemical Engineering
Ernst Hall Room 217
216 Eastern Parkway
Louisville, Kentucky 40208