Steven Koenig

Professor

Since joining UofL in 1996, Dr. Koenig has co-authored over 100 articles and received over $40 million in grants from NIH-SBIR and KSTC programs, Whitaker and AHA foundations, and industry sponsors that supported development of bioinstrumentation, data acquisition and analysis systems, and MCS device testing to demonstrate efficacy and safety in compliance with Good Laboratory Practice(GLP). Our efforts with pre-clinical testing (CII) and clinical trials (Jewish Hospital) have led to successful CE Mark and FDA approval.

Education

Ph.D. in Biomedical Engineering, University of Texas, 1996
M.S. in Electrical Engineering, University of New Hampshire, 1990
B.S. in Electrical Engineering, University of New Hampshire, 1989

Publications

Journal Articles
- Chen, Z., Jena, S., K., Giridharan, G., A., Koenig, S., C., Slaughter, M., S., Griffith, B., P. & Wu, Z. (2018). Flow features and device-induced blood trauma in CF-VADs under a pulsatile blood flow condition: A CFD comparative study. International Journal for Numerical Methods in Biomedical Engineering, 34(2)
- Chen, Z., Mondal, N., K., Cheng, S., Koenig, S., C., Slaughter, M., S., Griffith, B., P. & Wu, Z. (2018). High Shear Induces Platelet Dysfunction Leading to Enhanced Thrombotic Propensity and Diminished Hemostatic Capacity. Platelets
- Wang, Y., Koenig, S., C., Wu, Z., Slaughter, M., S. & Giridharan, G., A. (2018). Sensor-based physiologic control strategy for biventricular support with rotary blood pumps. ASAIO Journal, 64(3), 338-50
- Chen, Z., Jena, S., K., Giridharan, G., A., Sobieski, M., A., Koenig, S., C., Slaughter, M., S., Griffith, B., P. & Wu, Z. (2019). Shear Stress and Blood Trauma Under Constant and Pulse-Modulated Speed CF-VAD Operations: CFD Analysis of HVAD. Medical and Biological Engineering and Computing, 57(4), 807-18
- Chen, Z., Koenig, S., C., Slaughter, M., S., Griffith, B., P. & Wu, Z. (2018). Quantitative Characterization of Shear-Induced Platelet Receptor Shedding: Glycoprotein Ibα, Glycoprotein VI and Glycoprotein IIb/IIIa. ASAIO Journal, 64(6), 773-78
- Wang, Y., Koenig, S., C., Wu, Z., Slaughter, M., S. & Giridharan, G., A. (2019). Sensorless physiologic control, suction prevention, and flow balancing algorithm for rotary biventricular assist devices. IEEE Transactions of Control Systems Technology, 27, 717-29
- Mondal, N., K., Chen, Z., Chen, H., H., Sorensen, E., N., Pham, S., M., Sobieski, M., A., Koenig, S., C., Slaughter, M., S., Griffith, B., P. & Wu, Z. (2017). Mechanistic insight of platelet apoptosis leading to non-surgical bleeding among heart failure patients supported by continuous-flow left ventricular assist devices. Molecular and Cellular Biochemistry, 433(1), 125-37
- Wang, Y., Koenig, S., C., Sobieski, M., A., Slaughter, M., S. & Giridharan, G., A. (2017). Hemodynamic benefits of implantable, percutaneous, and intraaortic rotary blood pumps and counterpulsation devices: an in-silico and in-vitro study. Cardiovascular Engineering and Technology, 8(4), 439-52
- Carnahan, S., Koenig, S., C., Sobieski, M., A., Schumer, E., Monreal, G., Wang, Y., Choi, Y., Tompkins, L., H., Wu, Z., J., Slaughter, M., S. & Giridharan, G., A. (2017). Efficacy of subcutaneous electrocardiogram leads for synchronous timing during chronic counterpulsation therapy. ASAIO journal, 63(2), 134-38
- Mondal, N., K., Sobieski, M., A., Pham, S., M., Griffith, B., P., Koenig, S., C., Slaughter, M., S. & Wu, Z., J. (2017). Infection, oxidative stress and changes in circulating regulatory T cells of heart failure patients supported by continuous-flow ventricular assist devices. ASAIO journal, 63(2), 128-33
- Qureshi, M., Glower, J., Ewert, D. & Koenig, S., C. (2017). A novel idea to improve cardiac output of mechanical circulatory support devices by optimizing kinetic energy transfer available in forward moving aortic blood flow. Cardiovascular Engineering and Technology, 2(8), 131-44
- Soucy, K., G., Bartoli, C., Phillips, D., Giridharan, G., A., Sobieski, M., A., Wead, W., B., Dowling, R., D., Wu, Z., Prabhu, S., D., Slaughter, M., S. & Koenig, S., C. (2017). Continuous Flow Left Ventricular Assist Device Improves Relative Myocardial Perfusion in Chronic Heart Failure. Annals of Biomedical Engineering
- Soucy, K., G., Koenig, S., C. & Slaughter, M., S. (2017). Intra-aortic balloon pumps and continuous flow left ventricular assist devices: Don't let balloon pumps overstay their welcome. The Journal of Thoracic and Cardiovascular Surgery, 153(1), e9-e10
- Chen, Z., Mondal, N., K., Ding, J., Koenig, S., C., Slaughter, M., S. & Wu, Z., J. (2016). Paradoxical effect of nonphysiologic shear stress on platelets and von Willebrand Factor. Artificial Organs, 40(7), 659-68
- Chen, Z., S., Mondal, N., K., Ding, J., Koenig, S., C., Slaughter, M., S. & Wu, Z., J. (2016). Paradoxical Effect of Nonphysiological Shear Stress on Platelets and von Willebrand Factor. Artificial Organs, 40(7), 659-668
- Koenig, S., C. & Slaughter, M., S. (2016). ASAIO Top Rated Journal and Highlights of the 62nd ASAIO Conference. ASAIO journal, 62(5), 501-04
- Mondal, N., K., Sorensen, E., N., Pham, S., M., Koenig, S., C., Griffith, B., P., Slaughter, M., S. & Wu, Z., J. (2016). Systemic Inflammatory Response Syndrome in End-Stage Heart Failure Patients Following Continuous-Flow Left Ventricular Assist Device Implantation: Differences in Plasma Redox Status and Leukocyte Activation. Artificial Organs, 40(5), 434-443
- Chen, G., Mondal, N., K., Ding, J., Koenig, S., C., Slaugher, M., S., Griffith, B., P. & Wu, Z., J. (2015). Activation and shedding of platelet glycoprotein IIb/IIIa under non-physiological shear stress. Molecular Cellular Biochemistry, 409, 93-101
- Giridharan, G., A., Koenig, S., C., Soucy, K., Choi, Y., Pirbodaghi, T., Bartoli, C., R., Monreal, G., Schumer, E., Cheng, A. & Slaughter, M., S. (2015). Hemodynamic changes and retrograde flow in LVAD failure. ASAIO J, 61(3), 282-91
- Giridharan, G., A., Koenig, S., C., Soucy, K., Choi, Y., Pirbodaghi, T., Bartoli, C., R., Monreal, G., Shumer, E., Cheng, A. & Slaughter, M., S. (2015). Left ventricular volume unloading with axial and centrifugal rotary blood pumps. ASAIO J, 61(3), 292-300
- Giridharan, G., A., Koenig, S., C., Soucy, K., Choi, Y., Pirbodaghi, T., bartoli, C., monreal, G., sobieski, M., schumer, E., cheng, A. & slaughter, M. (2015). Hemodynamic changes and retrograde flow in LVAD failure. ASAIO J, 61(3), 282-291
- Giridharan, G., A., Koenig, S., C., Soucy, K., G., Choi, Y., Pirbodaghi, T., Bartoli, C., R., Monreal, G., Schumer, E., Cheng, A. & Slaugher, M., S. (2015). Left ventricular volume unloading with axial and centrifugal rotary blood pumps. ASAIO J, 61(3), 292-300
- Giridharan, G., A., Koenig, S., C., Soucy, K., G., Choi, Y., Pirbodaghi, T., Bartoli, C., R., Monreal, G., Schumer, E., Cheng, A. & Slaughter, M., S. (2015). Hemodynamic changes and retrograde flow in LVAD failure. ASAIO J, 61(3), 282-91
- Giridharan, G., A., Koenig, S., C., Soucy, K., choi, Y., Pirbodaghi, T., bartoli, C., monreal, G., sobieski, M., schumer, E., cheng, A. & slaughter, M. (2015). Left ventricular volume unloading with axial and centrifugal rotary blood pumps. ASAIO J, 61(3), 292-300
- Ising, M., S., Sobieski, M., A., Slaughter, M., S., Koenig, S., C. & Giridharan, G., A. (2015). Feasibility of pump speed modulation for restoring vascular pulsatility with rotary blood pumps. ASAIO J, 61(5), 562-32
- Soucy, K., G., Smith, E., F., Monreal, G., Rokosh, G., Keller, B., B., Yuan, F., Matheny, R., G., Fallon, A., M., Lewis, B., C., Sherwood, L., C., Sobieski, M., A., Giridharan, G., A., Koenig, S., C. & Slaughter, M., S. (2015). Feasibility study of particulate extracellular matrix (P-ECM) and left ventricular assist device (HVAD) therapy in chronic ischemic heart failure bovine model. ASAIO J, 61(2), 161-169
- Soucy, K., G., Smith, E., F., Monreal, G., Rokosh, G., Matheny, R., Lewis, B., Sherwood, L., Sobieski, M., A., Giridharan, G., A., Koenig, S., C. & Slaughter, M., S. (2015). Feasibility study of particulate extracellular matrix (P-ECM) and left ventricular assist device (HVAD) therapy in chronic ischemic heart failure bovine model. ASAIO J, 61(2), 161-9
- Soucy, K., Giridharan, G., A., Choi, Y., Sobieski, M., A., Monreal, G., Cheng, A., Schumer, E., Slaughter, M., S. & Koenig, S., C. (2015). Rotary pump speed modulation for generating pulsatile flow and phasic left ventricular volume unloading in bovine model of chronic ischemic heart failure. Journal of Heart and Lung Transplantation, 34(1), 122-31
- Soucy, K., Smith, E., F., Monreal, G., Rokosh, G., Matheny, R., Lewis, B., Sherwood, L., Sobieski, M., A., Giridharan, G., A., Koenig, S., C. & Slaughter, M., S. (2015). Feasibility study of particulate extracellular matrix (P-ECM) and left ventricular assist device (HVAD) therapy in chronic ischemic heart failure bovine model. ASAIO J, 61(2), 161-69
- Wang, Y., Koenig, S., C. & Slaughter, M., S. (2015). Suction prevention and physiologic control of continuous flow left ventricular assist devices using intrinsic pump parameters. ASAIO J, 61(2), 170-77
- Wang, Y., Koenig, S., C., Slaughter, M., S. & Giridharan, G., A. (2015). Rotary blood pump control strategy for preventing left ventricular suction. ASAIO J, 61(1), 21-30
- Wang, Y., Koenig, S., C., Slaughter, M., S. & Giridharan, G., A. (2015). Rotary blood pump control strategy for preventing left ventricular suction. ASAIO J, 61(1), 21-30
- Wang, Y., Koenig, S., C., Slaughter, M., S. & Giridharan, G., A. (2015). Suction prevention and physiologic control of continuous flow left ventricular assist devices using intrinsic pump parameters. ASAIO J, 62(2), 170-77
- Bartoli, C., R., Dassanayaka, S., Brittan, K., R., Luckett, A., Sithu, S., Siess, T., Raess, D., H., Spence, P., A., Koenig, S., C., Dowling, R., D. & D'Souza, S., E. (2014). Insights into the mechanisms of von Willebrand factor degradation during mechanical circulatory support. Journal of Thoracic and Cardiovascular Surgery, 147(5), 1634-43
- Bartoli, C., R., Dassanayaka, S., Brittian, K., R., Luckett, A., Sithu, S., Siess, T., Raess, D., Spence, P., A., Koenig, S., C., Dowling, R., D. & Prabhu, S., D. (2014). Insights into the mechanisms of von Willebrand factor degradation during mechanical circulatory support. , 147(5), 1634-43
- Bartoli, C., R., Spence, P., A., Koenig, S., C. & Dowling, R., D. (2014). Nonphysiologic blood flow triggers endothelial and arterial remodeling in vivo: implications for novel LVAD with a peripheral anastamosis. Journal Thoracic and Cardiovascular Surgery, 148, 311-21
- Bartoli, C., R., Spence, P., A., Siess, T., Raess, D., H., Koenig, S., C. & Dowling, R., D. (2014). Nonphysiologic blood flow triggers endothelial and arterial remodeling in vivo: implications for novel LVAD with a peripheral anastamosis. Journal of Thoracic and Cardiovascular Surgery, 148, 311-21
- Giridharan, G., A., Ising, M., Sobieski, M., A., Koenig, S., C., Chen, J., Frankel, S. & Rodefeld, M., D. (2014). Cavopulmonary assist for the failing Fontan circulation: impact of ventricular function on mechanical support strategy. ASAIO J, 60(6), 707-15
- Giridharan, G., A., Koenig, S., C. & Slaughter, M. (2014). Do axial flow LVADs unload better than centrifugal flow LVADs. ASAIO J, 60(2), 137-139
- Koenig, S., C., Jimenez, J., H., Sobieski, M., A., Choi, Y., Monreal, G., Giridharan, G., A., Soucy, K. & Slaughter, M., S. (2014). Early feasibility testing and engineering development of a universal sutureless beating heart (SBH) connector for left ventricular assist devices (LVAD). ASAIO J, 60(6), 617-25
- Monreal, G., Sherwood, L., C., Sobieski, M., A., Giridharan, G., A., Slaughter, M., S. & Koenig, S., C. (2014). Pre-clinical animal models for left ventricular assist device (LVAD) research and development. ASAIO Journal, 60(1), 2-8
- Monreal, G., Sherwood, L., Sobieski, M., Giridharan, G., A., Slaughter, M. & Koenig, S., C. (2014). Large animal models for left ventricular assist device research and development. ASAIO J, 60(1), 2-8
- Slaughter, M., S., Soucy, K., Matheny, R., Choi, Y., Monreal, G., Sobieski, M., A., Giridharan, G., A. & Koenig, S., C. (2014). Development of particulate extracellular matrix (P-ECM) delivery system for effective intramyocardial injection in ischemic tissue. ASAIO J, 60(6), 730-36
- Tamez, D., LaRose, J., Shambaugh, C., Chorpenning, K., Soucy, K., Sobieski, M., Sherwood, L., Giridharan, G., A., Monreal, G., Koenig, S., C. & Slaughter, M. (2014). Early feasibility testing and engineering development of the transapical approach for the heart ware MVAD ventricular assist system. ASAIO J, 60(2), 170-177
- Tamez, D., LaRose, J., Sobieski, M., Sherwood, L., C., Giridharan, G., A., Koenig, S., C. & Slaughter, M., S. (2014). Development of a transapical miniaturized ventricular assist device (tMVAD). ASAIO Journal, 60(2), 170-77
- Bartoli, C., Koenig, S., Ionan, C., Gillars, K., Mitchell, M., Austin, E., Gray, L. & Pantalos, G. (2013). Extracorporeal Membrane Oxygenation Versus Counterpulsatile, Pulsatile, and Continuous Left Ventricular Unloading for Pediatric Mechanical Circulatory Support. PEDIATRIC CRITICAL CARE MEDICINE, 14(9), E424-E437
- Bartoli, C., R., Koenig, S., C., Ionan, C., Gillars, K., J., Mitchell, M., E., Austin, E., H., Gray, L., A. & Pantalos, G., M. (2013). Extracorporeal membrane oxygenation vs counterpulsatile, pulsatile, and continuous blood flow for pediatric mechanical circulatory support. Pediatric Critica Care Medicine, 14(9), 424-37
- Bartoli, C., R., Sherwood, L., C., Giridharan, G., A., Slaughter, M., S., Wead, W., B., Prabhu, S., D. & Koenig, S., C. (2013). Bovine model of chronic ischemic cardiomyopathy: implications for ventricular assist device research. Artificial Organs, 37(12), 202-14
- Giridharan, G., A., Koenig, S., C., Kennington, J., Sobieski, M., A., Chen, J., Frankel, S., H., Rodefeld, M., D., Giridharan, G., Koenig, S., Sobieski, M., Chen, J. & Frankel, S. (2013). Performance evaluation of a pediatric viscous impeller pump for Fontan cavopulmonary assist. JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY, 145(1), 249-257
- Ising, M., Koenig, S., C., Sobieski, M., A., Slaughter, M., S. & Giridharan, G., A. (2013). Flow modulation algorithms for intra-aortic rotary blood pumps to minimize coronary steal. ASAIO Journal, 59(3), 261-68
- Kondo, K., Bhushan, S., King, A., L., Prabhu, S., D., Hamid, T., Koenig, S., C. & Murohara, T. (2013). H2S protects against pressure overload induced heart failure via upregulation of endothelial nitric oxide synthase (eNOS). Circulation, 127(10), 1116-27
- Sherwood, L., C., Sobieski, M., A., Koenig, S., C., Giridharan, G., A. & Slaughter, M., S. (2013). Benefits of aggressive medical management in a bovine model of chronic ischemic heart failure. ASAIO Journal, 59(3), 221-29
- Soucy, K., G., Graham, J., D., Benzinger, C., J., Sharp, M., K., Giridharan, G., A., Sobieski, M., A., Slaughter, M., S. & Koenig, S., C. (2013). Feasbility of ventricular-arterial cannula for aortic valve bypass. Cardiovascular Engineering and Technology, 4(2), 161-70
- Soucy, K., G., Koenig, S., C., Giridharan, G., A., Sobieski, M., A. & Slaughter, M., S. (2013). Defining pulsatility during continuous flow ventricular assist device support. Journal of Heart and Lung Tranplantation, 32(6), 581-87
- Soucy, K., G., Koenig, S., C., Giridharan, G., A., Sobieski, M., A. & Slaughter, M., S. (2013). Rotary pumps and diminished pulsatility: Do we need a pulse?. ASAIO Journal, 59(4), 355-66
- Soucy, K., G., Koenig, S., C., Sobieski, M., A., Slaughter, M., S. & Giridharan, G., A. (2013). Fault detection in rotary blood pumps using motor speed response. ASAIO Journal, 59(4), 410-19
- Soucy, K., Koenig, S., Giridharan, G., Sobieski, M. & Slaughter, M. (2013). Defining pulsatility during continuous-flow ventricular assist device support. JOURNAL OF HEART AND LUNG TRANSPLANTATION, 32(6), 581-587
- Bartoli, C., R., Dassanayaka, S., Brittian, K., Nadar, A., C., Ismahil, M., A., Koenig, S., C. & Prabhu, S., D. (2012). Direct measurement of blood flow in microvessels grown in Matrigel in vivo. The Journal of Surgical Research, 172(1), e55-60
- Bartoli, C., R., Wead, W., B., Giridharan, G., A., Prabhu, S., D. & Koenig, S., C. (2012). What is the culprit in coronary anomalies? Reply. Journal of Thoracic and Cardiovascular Surgery, 144(6), 1531-1533
- Bartoli, C., R., Wead, W., B., Giridharan, G., A., Prabhu, S., D., Koenig, S., C. & Dowling, R., D. (2012). Mechanism of myocardial ischemia with an anomalous left coronary artery from the right sinus of Valsalva. Journal of Thoracic and Cardiovascular Surgery, 144(2), 402-408
- Giridharan, G., A., Bartoli, C., R., Spence, P., A., Dowling, R., D. & Koenig, S., C. (2012). Counterpulsation with symphony prevents retrograde carotid, aortic, and coronary flows observed with intra-aortic balloon pump support. Artificial Organs, 36(7), 600-606
- Giridharan, G., A., Cheng, R., Glower, J., S., Ewert, D., L., Sobieski, M., A., Slaughter, M., S. & Koenig, S., C. (2012). Control strategies for afterload reduction with an artificial vasculature device. ASAIO Journal, 58(4), 353-362
- Giridharan, G., A., Lee, T., J., Ising, M., Sobieski, M., A., Koenig, S., C., Gray, L., A. & Slaughter, M., S. (2012). Miniaturization of mechanical circulatory support systems. Artificial Organs, 36(8), 731-739
- Sobieski, M., A., Giridharan, G., A., Ising, M., Koenig, S., C. & Slaughter, M., S. (2012). Blood trauma testing of CentriMag and RotaFlow centrifugal flow devices: a pilot study. Artificial Organs, 36(8), 677-682
- Warren, S., Giridharan, G., A., Dowling, R., D., Spence, P., A., Tompkins, L., Gratz, E., Sherwood, L., C., Sobieski, M., A., Bartoli, C., R., Slaughter, M., S., Keynton, R., S. & Koenig, S., C. (2012). Feasibility of subcutaneous ECG leads for synchronized timing of a counterpulsation device. Cardiovascular Engineering and Technology, 3(1), 17-25
- Warren, S., Giridharan, G., A., Dowling, R., D., Tompkins, L., Gratz, E., Sherwood, L., Sobieski, M., A., Bartoli, C., Spence, P., A., Keynton, R., S., Ehringer, W., D. & Koenig, S., C. (2012). Feasibility of Subcutaneous ECG Leads for Synchronized Timing of a Counterpulsation Device. Cardiovascular Engineering and Technology, 3(1), 17-25
- Kormos, R., L., Antonides, C., Goldstein, D., J., Cowger, J., A., Starling, R., C., Kirklin, J., K., Rame, J., E., Rosenthal, D., Mooney, M., L., Caliskan, K., Messe, S., R., Teuteberg, J., J., Mohacsi, P., Slaughter, M., S., Potapov, E., V., Rao, V., Schima, H., Stehlik, J., Joseph, S., Koenig, S., C. & Pagani, F., D. (2020). Updated definitions of adverse events for trials and registries of mechanical circulatory support: A consensus statement of the mechanical circulatory support academic research consortium. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation, 39(8), 735-750
- Tompkins, L., H., Gellman, B., N., Morello, G., F., Prina, S., R., Roussel, T., J., Kopechek, J., A., Petit, P., C., Slaughter, M., S., Koenig, S., C. & Dasse, K., A. (2020). Design and Computational Evaluation of a Pediatric MagLev Rotary Blood Pump. ASAIO journal (American Society for Artificial Internal Organs : 1992)

More about Steven Koenig

- ASAIO Top Five - Student Medical Device Design Competition, , ASAIO
- 1st Place Medical Device Entrepreneur's Forum (Landon Tompkins, PhD student), 2018, 64th Annual ASAIO conference (Washington DC)
- Distinguished Faculty Award in Reearch for Basic and Applied Sciences, 2014, University of Louisville
- Endowed Chair Cardiac Implant Science, 2013, University of Louisville
2020
Spring
- BE 423 - BIOENGR MEASUREMENTS LAB
- BE 423 - BIOENGR MEASUREMENTS LAB
- BE 480 - BIOMEDICAL DEVICE DESIGN
2019
Spring
- BE 480 - BIOMEDICAL DEVICE DESIGN
- BE 423 - BIOENGR MEASUREMENTS LAB
- BE 423 - BIOENGR MEASUREMENTS LAB
2018
Spring
- BE 480 - BIOMEDICAL DEVICE DESIGN
2017
Spring
- BE 480 - BIOMEDICAL DEVICE DESIGN
2016
Spring
- BE 480 - BIOMEDICAL DEVICE DESIGN
2015
Spring
- BE 480 - BIOMEDICAL DEVICE DESIGN
2014
Spring
- BE 480 - BIOMEDICAL DEVICE DESIGN

Steven Koenig

Education

Publications

Additional Publications

More about Steven Koenig

Awards and Recognition

Courses Taught