Joseph Chen

Asst Professor

Dr. Chen is an Assistant Professor in the Department of Bioengineering at the University of Louisville. His research interests include investigating the mechanobiological drivers of disease progression, with a focus on neurodegeneration and glioblastoma invasion. His lab leverages tools from the fields of biomaterials, biomechanics, and gene editing to tease out the underlying mechanobiological pathways in disease.

Dr. Chen received his BS and MS from the Department of Agricultural and Biological Engineering at Mississippi State University, where he worked in the lab of Jun Liao and studied valvuar biomechanics and tissue engineering. He then earned his PhD in the Department of Biomedical Engineering at Vanderbilt University, where he studied the impact of mechanical strain on the progression of aortic valve disease in the lab of W. David Merryman. Prior to arriving at Louisville, Dr. Chen worked as a postdoctoral fellow in the lab of Sanjay Kumar at the University of California, Berkeley. His postdoctoral work focused on investigating the impact of cytoskeletal regulators in glioblastoma invasion and elucidating the underlying mechanisms that drive mesenchymal shifting in glioblastoma.


  • B.S. in Biomedical Engineering, Mississippi State University, 2008
  • M.S. in Biomedical Engineering, Mississippi State University, 2010
  • Ph.D. in Biomedical Engineering, Vanderbilt University, 2015


Suppression of LIM Kinase 1 and LIM Kinase 2 Limits Glioblastoma Invasion- 2020
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